Familial mesothelioma in first degree relatives

Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupa...

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Bibliographic Details
Published in:Diagnostic cytopathology 2013-07, Vol.41 (7), p.654-657
Main Authors: Kalogeraki, Alexandra M., Tamiolakis, Dimitrios J., Lagoudaki, Eleni D., Papadakis, Michael N., Papadakis, George Z., Agelaki, Sofia I., Stathopoulos, Efstathios N., Tzardi, Maria N.
Format: Article
Language:English
Subjects:
Adult
Asbestos - adverse effects
Biomarkers, Tumor - metabolism
cytology
familial malignant mesothelioma
Family
Family Health
Female
Genetic Predisposition to Disease
Humans
Male
Mesothelioma - chemically induced
Mesothelioma - genetics
Mesothelioma - metabolism
Mesothelioma - pathology
Occupational Exposure - adverse effects
oncology
pathology
Pleural Neoplasms - chemically induced
Pleural Neoplasms - genetics
Pleural Neoplasms - metabolism
Pleural Neoplasms - pathology
Smoking
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Summary:Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.21859