Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis

Background Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power. Methods The approach was a literature search for longitudinal studies of biomarkers in OPSC...

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Published in:Head & neck 2013-07, Vol.35 (7), p.1048-1055
Main Authors: Rainsbury, James W., Ahmed, Waseem, Williams, Hazel K., Roberts, Sally, Paleri, Vinidh, Mehanna, Hisham
Format: Article
Language:English
Subjects:
biomarker
Biomarkers, Tumor
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - virology
human papillomavirus
Humans
oropharyngeal cancer
Oropharyngeal Neoplasms - complications
Oropharyngeal Neoplasms - mortality
Oropharyngeal Neoplasms - virology
Papillomaviridae
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Prognosis
prognostic
survival
Survival Rate
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Summary:Background Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power. Methods The approach was a literature search for longitudinal studies of biomarkers in OPSCC, with systematic review and meta‐analysis. Results In all, 3130 articles were identified; 32 satisfied the inclusion and exclusion criteria. On meta‐analysis, there was a significant overall survival (OS) benefit for patients with HPV positive and p16 positive tumors. There was some evidence of improved OS of OPSCC patients with raised bcl2; amplification of 11q3 and loss of 16q genes; and low c‐met, ki67, IMD, PLK, FHIT, nuclear surviving, or nuclear cyclin D1. However, none of these was suitable for meta‐analysis. Conclusion Survival from OPSCC is associated with several biomarkers, which constitute potential targets for research into improving the prognostic power of HPV in OPSCC. Larger trials are needed, with standardization of cut‐points and adherence to consensus reporting guidelines. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.22950