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Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis
Background Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power. Methods The approach was a literature search for longitudinal studies of biomarkers in OPSC...
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| Published in: | Head & neck 2013-07, Vol.35 (7), p.1048-1055 |
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| Main Authors: | , , , , , |
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| container_end_page | 1055 |
| container_issue | 7 |
| container_start_page | 1048 |
| container_title | Head & neck |
| container_volume | 35 |
| creator | Rainsbury, James W. Ahmed, Waseem Williams, Hazel K. Roberts, Sally Paleri, Vinidh Mehanna, Hisham |
| description | Background
Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power.
Methods
The approach was a literature search for longitudinal studies of biomarkers in OPSCC, with systematic review and meta‐analysis.
Results
In all, 3130 articles were identified; 32 satisfied the inclusion and exclusion criteria. On meta‐analysis, there was a significant overall survival (OS) benefit for patients with HPV positive and p16 positive tumors. There was some evidence of improved OS of OPSCC patients with raised bcl2; amplification of 11q3 and loss of 16q genes; and low c‐met, ki67, IMD, PLK, FHIT, nuclear surviving, or nuclear cyclin D1. However, none of these was suitable for meta‐analysis.
Conclusion
Survival from OPSCC is associated with several biomarkers, which constitute potential targets for research into improving the prognostic power of HPV in OPSCC. Larger trials are needed, with standardization of cut‐points and adherence to consensus reporting guidelines. © 2012 Wiley Periodicals, Inc. Head Neck, 2013 |
| doi_str_mv | 10.1002/hed.22950 |
| format | article |
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Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power.
Methods
The approach was a literature search for longitudinal studies of biomarkers in OPSCC, with systematic review and meta‐analysis.
Results
In all, 3130 articles were identified; 32 satisfied the inclusion and exclusion criteria. On meta‐analysis, there was a significant overall survival (OS) benefit for patients with HPV positive and p16 positive tumors. There was some evidence of improved OS of OPSCC patients with raised bcl2; amplification of 11q3 and loss of 16q genes; and low c‐met, ki67, IMD, PLK, FHIT, nuclear surviving, or nuclear cyclin D1. However, none of these was suitable for meta‐analysis.
Conclusion
Survival from OPSCC is associated with several biomarkers, which constitute potential targets for research into improving the prognostic power of HPV in OPSCC. Larger trials are needed, with standardization of cut‐points and adherence to consensus reporting guidelines. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.22950</identifier><identifier>PMID: 22997051</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>biomarker ; Biomarkers, Tumor ; Carcinoma, Squamous Cell - complications ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - virology ; human papillomavirus ; Humans ; oropharyngeal cancer ; Oropharyngeal Neoplasms - complications ; Oropharyngeal Neoplasms - mortality ; Oropharyngeal Neoplasms - virology ; Papillomaviridae ; Papillomavirus Infections - complications ; Papillomavirus Infections - virology ; Prognosis ; prognostic ; survival ; Survival Rate</subject><ispartof>Head & neck, 2013-07, Vol.35 (7), p.1048-1055</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4570-3f5c1701ee08ed1d7d0532b83465a196b064540458e0e41c6a944a223df6a5be3</citedby><cites>FETCH-LOGICAL-c4570-3f5c1701ee08ed1d7d0532b83465a196b064540458e0e41c6a944a223df6a5be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22997051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rainsbury, James W.</creatorcontrib><creatorcontrib>Ahmed, Waseem</creatorcontrib><creatorcontrib>Williams, Hazel K.</creatorcontrib><creatorcontrib>Roberts, Sally</creatorcontrib><creatorcontrib>Paleri, Vinidh</creatorcontrib><creatorcontrib>Mehanna, Hisham</creatorcontrib><title>Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power.
Methods
The approach was a literature search for longitudinal studies of biomarkers in OPSCC, with systematic review and meta‐analysis.
Results
In all, 3130 articles were identified; 32 satisfied the inclusion and exclusion criteria. On meta‐analysis, there was a significant overall survival (OS) benefit for patients with HPV positive and p16 positive tumors. There was some evidence of improved OS of OPSCC patients with raised bcl2; amplification of 11q3 and loss of 16q genes; and low c‐met, ki67, IMD, PLK, FHIT, nuclear surviving, or nuclear cyclin D1. However, none of these was suitable for meta‐analysis.
Conclusion
Survival from OPSCC is associated with several biomarkers, which constitute potential targets for research into improving the prognostic power of HPV in OPSCC. Larger trials are needed, with standardization of cut‐points and adherence to consensus reporting guidelines. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><subject>biomarker</subject><subject>Biomarkers, Tumor</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>human papillomavirus</subject><subject>Humans</subject><subject>oropharyngeal cancer</subject><subject>Oropharyngeal Neoplasms - complications</subject><subject>Oropharyngeal Neoplasms - mortality</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - virology</subject><subject>Prognosis</subject><subject>prognostic</subject><subject>survival</subject><subject>Survival Rate</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kUtv1DAUhS0EoqWw4A8gS2xgkfb6PWFXlT6QBqhEgaXlJDetSxJP7cm0-fc4TIcFEitbV985OjqHkNcMDhkAP7rB5pDzUsETss-gNAUIaZ7OfykKAUbukRcp3QKA0JI_J3sZLg0otk_CZQzXQ0hrX9PKh97FXxgTDS1NY9z4jeuoH2iIYXXj4jRcYz6ku9H1YUy0xq6jtYu1H7LyA_02pTX2bvaKuPF4T93Q0B7XrnCD66bk00vyrHVdwleP7wH5fnZ6dXJRLL-efzo5Xha1VAYK0aqaGWCIsMCGNaYBJXi1EFIrx0pdgZZKglQLBJSs1q6U0nEumlY7VaE4IO-2vqsY7kZMa9v7NOd1A-bolgkDWkjJZUbf_oPehjHmvDOlS6OEYjpT77dUHUNKEVu7ij7XNVkGdl7B5hXsnxUy--bRcaz6fN2Ru9ozcLQF7n2H0_-d7MXpx51lsVX4XPHDX0Wey2ojjLI_v5zbq0v4sfzMwQrxGx5boF4</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Rainsbury, James W.</creator><creator>Ahmed, Waseem</creator><creator>Williams, Hazel K.</creator><creator>Roberts, Sally</creator><creator>Paleri, Vinidh</creator><creator>Mehanna, Hisham</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis</title><author>Rainsbury, James W. ; Ahmed, Waseem ; Williams, Hazel K. ; Roberts, Sally ; Paleri, Vinidh ; Mehanna, Hisham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4570-3f5c1701ee08ed1d7d0532b83465a196b064540458e0e41c6a944a223df6a5be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>biomarker</topic><topic>Biomarkers, Tumor</topic><topic>Carcinoma, Squamous Cell - complications</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>human papillomavirus</topic><topic>Humans</topic><topic>oropharyngeal cancer</topic><topic>Oropharyngeal Neoplasms - complications</topic><topic>Oropharyngeal Neoplasms - mortality</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - virology</topic><topic>Prognosis</topic><topic>prognostic</topic><topic>survival</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rainsbury, James W.</creatorcontrib><creatorcontrib>Ahmed, Waseem</creatorcontrib><creatorcontrib>Williams, Hazel K.</creatorcontrib><creatorcontrib>Roberts, Sally</creatorcontrib><creatorcontrib>Paleri, Vinidh</creatorcontrib><creatorcontrib>Mehanna, Hisham</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rainsbury, James W.</au><au>Ahmed, Waseem</au><au>Williams, Hazel K.</au><au>Roberts, Sally</au><au>Paleri, Vinidh</au><au>Mehanna, Hisham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2013-07</date><risdate>2013</risdate><volume>35</volume><issue>7</issue><spage>1048</spage><epage>1055</epage><pages>1048-1055</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Human papillomavirus (HPV) positivity improves prognosis in patients with oropharyngeal squamous cell carcinoma (OPSCC). Combining HPV status with other biomarkers may improve its prognostic power.
Methods
The approach was a literature search for longitudinal studies of biomarkers in OPSCC, with systematic review and meta‐analysis.
Results
In all, 3130 articles were identified; 32 satisfied the inclusion and exclusion criteria. On meta‐analysis, there was a significant overall survival (OS) benefit for patients with HPV positive and p16 positive tumors. There was some evidence of improved OS of OPSCC patients with raised bcl2; amplification of 11q3 and loss of 16q genes; and low c‐met, ki67, IMD, PLK, FHIT, nuclear surviving, or nuclear cyclin D1. However, none of these was suitable for meta‐analysis.
Conclusion
Survival from OPSCC is associated with several biomarkers, which constitute potential targets for research into improving the prognostic power of HPV in OPSCC. Larger trials are needed, with standardization of cut‐points and adherence to consensus reporting guidelines. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22997051</pmid><doi>10.1002/hed.22950</doi><tpages>8</tpages></addata></record> |
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| subjects | biomarker Biomarkers, Tumor Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - virology human papillomavirus Humans oropharyngeal cancer Oropharyngeal Neoplasms - complications Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - virology Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - virology Prognosis prognostic survival Survival Rate |
| title | Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis |
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