Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development

Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification of the skin. Keratin-19 is an epithelial marker and a potential marker of epidermal stem cells that is expressed during human fetal skin development. We examined the immunohistochemical express...

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Bibliographic Details
Published in:Archives of Dermatological Research 2013-07, Vol.305 (5), p.379-387
Main Authors: Gkegkes, Ioannis D., Aroni, Kyriaki, Agrogiannis, George, Patsouris, Efstratios S., Konstantinidou, Anastasia E.
Format: Article
Language:English
Subjects:
Autopsy
Biomarkers - analysis
Caspases - analysis
Cell Differentiation
Dermatology
Epidermis - chemistry
Epidermis - embryology
Epidermis - enzymology
Epithelial Cells - chemistry
Epithelial Cells - enzymology
Gestational Age
Hair Follicle - chemistry
Hair Follicle - embryology
Hair Follicle - enzymology
Humans
Immunohistochemistry
Infant, Newborn
Keratin-19 - analysis
Medicine
Medicine & Public Health
Original Paper
Retrospective Studies
Sebaceous Glands - chemistry
Sebaceous Glands - embryology
Sebaceous Glands - enzymology
Sweat Glands - chemistry
Sweat Glands - embryology
Sweat Glands - enzymology
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Summary:Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification of the skin. Keratin-19 is an epithelial marker and a potential marker of epidermal stem cells that is expressed during human fetal skin development. We examined the immunohistochemical expression of caspase-14 in relation to CK-19 in the human fetal skin during development and perinatally, to assess their role in human skin maturation. Skin samples were received at autopsy. In the fetal epidermis, caspase-14 was predominantly expressed in the more differentiated layers, gradually disappearing from the basal layer toward term. By contrast, keratin-19 expression gradually decreased with epidermal maturation through gestation (rho = −0.949; p  = 0.0001) and was a marker of the germinative layers. Keratin-19 was preserved in scarce basal cell nests at term and postnatally. Caspase-14 and keratin-19 were inversely expressed in the differentiating epidermal layers through gestation ( p  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-013-1319-8