Serum carboxy-terminal telopeptide of type I collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients: A pilot study

Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs...

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Bibliographic Details
Published in:Atherosclerosis 2013-07, Vol.229 (1), p.182-185
Main Authors: Kato, Shuji, Endo, Itsuro, Fujimura, Mitsunori, Kuriwaka-Kido, Rika, Fujinaka, Yuichi, Aihara, Ken-ichi, Iwase, Takashi, Inoue, Daisuke, Akaike, Masashi, Abe, Masahiro, Matsumoto, Toshio
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - epidemiology
Acute Coronary Syndrome - pathology
Aged
Aged, 80 and over
atherosclerosis
Biomarkers - blood
blood serum
bone diseases
Cardiovascular
collagen
Collagen Type I - blood
Coronary Artery Disease - blood
Coronary Artery Disease - epidemiology
Coronary Artery Disease - pathology
coronary disease
correlation
Cross-Sectional Studies
digestion
Female
Humans
ICTP
macrophages
Male
Matrix metalloproteinase
Matrix Metalloproteinases - metabolism
men
Middle Aged
Morbidity
multivariate analysis
Necrosis
Necrotic core
patients
Peptides - blood
Pilot Projects
Plaque, Atherosclerotic - blood
Plaque, Atherosclerotic - epidemiology
Plaque, Atherosclerotic - pathology
renal failure
Risk Factors
Type I collagen
ultrasonography
Vulnerable plaque
women
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Summary:Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2013.03.030