Effects of estradiol or testosterone treatment on expression of gonadotropin subunit mRNAs and proteins in the pituitary of juvenile brown hagfish, Paramyxine atami

Highlights • Sex steroids regulate hagfish pituitary GTH functions negatively. • Estradiol does not suppress GTH mRNA levels, but suppress GTH secretion in hagfish. • Testosterone suppresses both mRNA levels and secretion of GTH in hagfish. • Hypothalamic–pituitary–gonadal feedback system functions...

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Bibliographic Details
Published in:General and comparative endocrinology 2013-08, Vol.189, p.111-118
Main Authors: Nozaki, Masumi, Uchida, Katsuhisa, Honda, Kaori, Shimotani, Toyokazu, Nishiyama, Maki
Format: Article
Language:English
Subjects:
Agnathan
Animals
Endocrinology & Metabolism
Estradiol
Estradiol - pharmacology
Female
Gonadotropin
Gonadotropins - genetics
Hagfish
Hagfishes - drug effects
Hagfishes - metabolism
Male
Pituitary gland
Pituitary Gland - drug effects
Pituitary Gland - metabolism
RNA, Messenger - metabolism
Testosterone
Testosterone - pharmacology
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Summary:Highlights • Sex steroids regulate hagfish pituitary GTH functions negatively. • Estradiol does not suppress GTH mRNA levels, but suppress GTH secretion in hagfish. • Testosterone suppresses both mRNA levels and secretion of GTH in hagfish. • Hypothalamic–pituitary–gonadal feedback system functions in hagfish.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.04.034