Fatal encephalitis due to BK virus in a patient with common variable immunodeficiency: A case report

Abstract Encephalitis due to BK virus is a rare condition. Here, we describe a young male patient with common variable immunodeficiency who developed fatal encephalitis due to BK virus. The patient presented initially with ocular symptoms that were followed by behavioral changes and spastic quadripa...

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Bibliographic Details
Published in:Journal of clinical virology 2013-08, Vol.57 (4), p.363-369
Main Authors: Bakri, Faris G, Bahou, Yacoub G, Al-Sammarrai, Firas A, Hadidy, Azmy, Gharaibeh, Almutez, Zaid, Ghida K, Mahafzah, Azmi, Samara, Osama A, Ababneh, Nidaa A, Zak, Imad
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
BK virus
BK Virus - genetics
BK Virus - isolation & purification
Common variable immunodeficiency
Common Variable Immunodeficiency - immunology
Common Variable Immunodeficiency - virology
DNA, Viral - genetics
Encephalitis
Encephalitis, Viral - immunology
Encephalitis, Viral - virology
Humans
Infectious Disease
Male
Polyoma virus
Polyomavirus Infections - immunology
Polyomavirus Infections - virology
Tumor Virus Infections - immunology
Tumor Virus Infections - virology
Young Adult
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Summary:Abstract Encephalitis due to BK virus is a rare condition. Here, we describe a young male patient with common variable immunodeficiency who developed fatal encephalitis due to BK virus. The patient presented initially with ocular symptoms that were followed by behavioral changes and spastic quadriparesis. Diagnosis was made by the compatible clinical findings and detection of viral DNA by polymerase chain reaction in the cerebrospinal fluid. To the best of our knowledge, this is the first report of BK virus encephalitis in a patient with common variable immunodeficiency. We suggest that BK virus should be suspected in cases of encephalitis; particularly in patients with immunodeficiency.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2013.04.016