The immunomodulatory effects of statins in community-acquired pneumonia: A systematic review

Summary Objective To evaluate the potential immunomodulatory effects of statins in community-acquired pneumonia. Methods We performed a systematic review of available literature on experimental and clinical studies. We used a PubMed/MEDLINE and EMBASE search to identify potential articles. Results W...

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Bibliographic Details
Published in:The Journal of infection 2013-08, Vol.67 (2), p.93-101
Main Authors: Troeman, D.P.R, Postma, D.F, van Werkhoven, C.H, Oosterheert, J.J
Format: Article
Language:English
Subjects:
Anticholesteremic Agents - therapeutic use
Biological and medical sciences
Community-acquired infections
Community-Acquired Infections - immunology
Community-Acquired Infections - pathology
General aspects
HMG-CoA
Humans
Immunologic Factors - therapeutic use
Immunomodulation
Immunosuppression
Infectious Disease
Medical sciences
Pneumology
Pneumonia
Pneumonia, Bacterial - immunology
Pneumonia, Bacterial - pathology
Respiratory system : syndromes and miscellaneous diseases
Review
Statins
Systematic
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Summary:Summary Objective To evaluate the potential immunomodulatory effects of statins in community-acquired pneumonia. Methods We performed a systematic review of available literature on experimental and clinical studies. We used a PubMed/MEDLINE and EMBASE search to identify potential articles. Results We identified 34 original studies, 17 experimental and 17 clinical studies, published up to March 2013. Conclusions Statins attenuated pulmonary inflammation by modulating neutrophil function, by reducing cytokine expression and release, and by protecting against disruption of pulmonary integrity. However, additional experimental studies are needed to fully elucidate the exact mechanisms. Several clinical studies suggested a decreased risk of CAP or a reduction in mortality due to CAP for current statin users, but the mostly observational design of these studies hampers the interpretation of their results. Therefore, appropriately designed studies, such as randomised controlled trials, are required to demonstrate the usefulness of statins in the prevention and treatment of CAP.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.04.015