IL-8 but not other biomarkers of endothelial damage is associated with disease activity in patients with ankylosing spondylitis without treatment with anti-TNF agents

• Published in: Rheumatology international 2013-07, Vol.33 (7), p.1779-1783
• Main Authors: Azevedo, Valderilio Feijó, Faria-Neto, J. R., Stinghen, Andrea, Lorencetti, Pedro G., Miller, Wagner P., Gonçalves, Beatriz P., Szyhta, Carla C., Pecoits-Filho, Roberto
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - immunology; Chemokine CCL2 - blood; Endothelium, Vascular - immunology; Female; Humans; Intercellular Adhesion Molecule-1 - blood; Interleukin-8 - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Predictive Value of Tests; Prognosis; Quality of Life; Rheumatology; Risk Factors; Severity of Illness Index; Spondylitis, Ankylosing - blood; Spondylitis, Ankylosing - diagnosis; Spondylitis, Ankylosing - immunology; Spondylitis, Ankylosing - psychology; Surveys and Questionnaires; Vascular Cell Adhesion Molecule-1 - blood
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-012-2631-x

The objective of the study was to investigate the association between IL-8 and other biomarkers of endothelial dysfunction (MCP-1, V-CAM, I-CAM) and the disease activity scores in a sample of 54 patients with ankylosing spondylitis (AS) without use of biological agents. Fifty-four AS patients without treatment with anti-TNFs agents between 18 and 80 years old, who met modified New York criteria and at the same time the axial ASAS criteria, were evaluated using an epidemiological questionnaire that included among others clinical data, BASDAI, BASFI, ASQoL, ASDAS and plasma levels of CRP, ESR, MCP-1, IL-8, ICAM-1 and VCAM-1. IL-8 varied in proportion to disease activity rates (BASDAI and ASDAS) p