Low-temperature atmospheric plasma increases the expression of anti-aging genes of skin cells without causing cellular damages

Efforts to employ various types of plasma in the field of skin care have increased consistently because it can regulate many biochemical reactions that are normally unaffected by light-based therapy. One method for skin rejuvenation adopted a high-temperature plasma generator to remove skin epitheli...

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Bibliographic Details
Published in:Archives of Dermatological Research 2013-03, Vol.305 (2), p.133-140
Main Authors: Choi, Jeong-Hae, Lee, Hyun-Wook, Lee, Jae-Koo, Hong, Jin-woo, Kim, Gyoo-cheon
Format: Article
Language:English
Subjects:
Animals
Apoptosis - radiation effects
Atmosphere
Cell death
Collagen - genetics
Collagen - metabolism
Dermatology
Fibronectins - genetics
Fibronectins - metabolism
Gene Expression Regulation - radiation effects
Humans
Keratinocytes - pathology
Keratinocytes - radiation effects
Medicine
Medicine & Public Health
Mice
Microwaves
NIH 3T3 Cells
Original Paper
Plasma Gases
Plasma Skin Regeneration - instrumentation
Plasma Skin Regeneration - methods
Skin Aging - genetics
Skin Aging - pathology
Skin Aging - radiation effects
Temperature
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
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Summary:Efforts to employ various types of plasma in the field of skin care have increased consistently because it can regulate many biochemical reactions that are normally unaffected by light-based therapy. One method for skin rejuvenation adopted a high-temperature plasma generator to remove skin epithelial cells. In this case, the catalyzing effects of the plasma were rarely used due to the high temperature. Hence, the benefits of the plasma were not magnified. Recently, many types of low-temperature plasma devices have been developed for medical applications but their detailed functions and working mechanisms are unclear. The present study examined the effect of low-temperature microwave plasma on skin cells. Treatment with low-temperature plasma increased the expression of anti-aging genes in skin cells, including collagen, fibronectin and vascular endothelial growth factor. Furthermore, the plasma treatment did not cause cell death, but only induced slight cell growth arrest at the G2 phase. Although the cells treated with low-temperature plasma showed moderate growth arrest, there were no signs of thermal or genetic damage of skin cells. Overall, this low-temperature microwave plasma device induces the expressions of some anti-aging-related genes in skin cells without causing damage.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-012-1259-8