Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats

The goal of this study was to evaluate and compare the effects of the aqueous extract of the seeds of chicory, Cichorium intybus L., on glucose tolerance test (GTT) and blood biochemical indices of experimentally-induced hyperglycemic rats. Late stage and early stage of Type 2 diabetes mellitus were...

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Bibliographic Details
Published in:Daru 2012-10, Vol.20 (10), p.1-1
Main Authors: Ghamarian, Abdolreza, Abdollahi, Mohammad, Su, Xiaogang, Amiri, Azita, Ahadi, Ali, Nowrouzi, Azin
Format: Article
Language:English
Subjects:
Cichorium intybus
Diabetes
Insulin
Insulin resistance
Medical research
Rodents
Seeds
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Summary:The goal of this study was to evaluate and compare the effects of the aqueous extract of the seeds of chicory, Cichorium intybus L., on glucose tolerance test (GTT) and blood biochemical indices of experimentally-induced hyperglycemic rats. Late stage and early stage of Type 2 diabetes mellitus were induced in rats by streptozotocin (STZ) and a combination of STZ and niacinamide (NIA/STZ), respectively. Within each group, one subgroup received daily i. p. injections of chicory extract (125 mg/kg body weight, for 28 days). Body weight and fasting blood sugar (FBS) were measured weekly. During the 4 weeks of treatment, chicory prevented body-weight loss and decreased FBS. ALT activities and levels of TG, TC and HbA1c decreased, and the concentration of NO increased in the chicory treated groups (p < 0.05). Unlike late-stage diabetes, fasting serum insulin concentrations were higher and GTT pattern approximated to normal in chicory-treated early-stage diabetic rats.
ISSN:1560-8115
2008-2231