The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing

• Published in: Daru 2012-10, Vol.20 (10), p.1-1
• Main Authors: Mirrahimi, Bahador, Hamishehkar, Hadi, Ahmadi, Arezo, Mirjalili, Mohamad Reza, Aghamohamadi, Mostafa, Najafi, Atabak, Abdollahi, Mohammad, Mojtahedzahed, Mojtaba
• Format: Article
• Language: English
• Subjects: Blood diseases; Clinical trials; Drug dosages; Magnesium; Oxidative stress; Teaching hospitals
• ISSN: 1560-8115; 2008-2231

In this study, two dosing regimens of magnesium were compared with a placebo control group in order to investigate the safety and efficacy of high doses of intravenous magnesium sulfate infusion on critically ill trauma patients. Forty-five trauma patients with systemic inflammatory response syndromes (SIRS) were randomly assigned into 2 treatment and one placebo groups. The high dose group received 15 g MgSO^sub 4^, low dose group received 7.5 g of MgSO^sub 4^ over 4 hour infusion, and placebo group received saline alone. The initial and post magnesium sulfate injection levels of tumor necrosis factor alpha (TNF-α), total antioxidant power and lipid peroxidation were measured after 6, 18 and 36 hours. Repeated measurements illustrated that there was no significant difference in TNF-α, total antioxidant power and lipid peroxidation levels among the groups during the period of analysis. The microalbuminuria at 36 hour post infusion of the high dose group was lower than that of the control group (p = 0.024).