Interaction between ALOX5AP-SG13S114AIT and COX-2-765GIC increases susceptibility to cerebral infarction in a Chinese population

• Published in: Genetics and molecular research 2013-01, Vol.12 (2), p.1660-1669
• Main Authors: Yi, X Y, Zhou, Q, Lin, J, Chi, L F, Chi, W Z
• Format: Article
• Language: English
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2013.May.14.6

We made a case-control study to investigate a possible association between ALOX5AP-SG13S114AIT, COX-2-765GIC, and COX-1-50CIT polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ALOX5AP-SG13S114AIT (rs10507391), COX-2-765GIC (rs20417), and COX-1-50CIT (rs3842787) polymorphisms were determined using PCR-RFLP. The generalized multifactor dimensionality reduction method was employed to detect gene-gene interactions. Based on single-gene analysis, there were no significant differences in the genotype and allele frequency distributions of ALOX5AP-SG13S114AIT, COX-2-765GIC, and COX-1-50C/T between the cerebral infarction group and controls. However, in those cases carrying ALOX5AP-SG13S114AA as well as COX-2-765CC, the risk of cerebral infarction increased significantly by 2.84 times (95%CI = 1.324-6.543). The single-gene ALOX5AP-SG13S114AIT, COX-2-765GIC, and COX-1-50CIT polymorphisms appear not to be associated with the development of cerebral infarction in Chinese populations. However, the interaction between ALOX5AP-SG13S114AA and COX-2-765CC apparently increases susceptibility to cerebral infarction.