Stereotactic radiosurgery for the treatment of brain metastases; results from a single institution experience

Background Stereotactic radiosurgery is frequently used for the treatment of brain metastases. This study provides a retrospective evaluation of patients with secondary lesions of the brain treated with stereotactic radiosurgery (SRS) at our institution. Aims To provide outcome data from a single in...

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Bibliographic Details
Published in:Irish journal of medical science 2013-09, Vol.182 (3), p.481-485
Main Authors: Burke, D., Mascott, C., Rock, L., Callinan, S., Mihai, A., Thirion, P., Armstrong, J. G.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain - surgery
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Family Medicine
Female
General Practice
Humans
Internal Medicine
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Radiosurgery - methods
Retrospective Studies
Salvage Therapy
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Summary:Background Stereotactic radiosurgery is frequently used for the treatment of brain metastases. This study provides a retrospective evaluation of patients with secondary lesions of the brain treated with stereotactic radiosurgery (SRS) at our institution. Aims To provide outcome data from a single institutional experience with SRS and identify any significant prognostic factors in the cohort. Methods Sixty-seven patients received first time SRS to 86 intracranial metastases between 2007 and 2010. Sixteen patients were excluded from this study due to the absence of post-treatment neuroimaging, resulting in 51 patients with 64 treated lesions. Of these patients, 37 (72.5 %) received SRS electively, while 14 (27.5 %) received salvage SRS after brain metastasis progression following whole brain radiotherapy. Results Median survival for the entire group was 15 months from the date of radiosurgery. Patients without active extracranial disease had statistically significant survival time than those with active extracranial disease ( P  = 0.03). 45 (70.3 %) lesions achieved local tumour control in 34 patients (66.7 %) with a mean follow-up period of 10.7 months (range 1.7–33.6 months, 95 % confidence interval 6.6–9.8 months). Conclusions The results reported in this study equate to those reported in other series consolidating SRS as an effective treatment option with few serious complications. Developments in systemic disease control will see further improvements in overall survival.
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-013-0918-x