Characterization of the mechanical and biological properties of a new alumina scaffold

In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. The results obtained showed that this scaffold has high...

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Bibliographic Details
Published in:Journal of applied biomaterials & functional materials 2013-01, Vol.11 (1), p.e18-25
Main Authors: Batista, Patrícia S P, Rodrigues, Miguel A A, Silva, Daniela M R, Morgado, Patrícia I C, Henriques, Joaquim P, Almeida, Maria O, Silva, Abílio P, Correia, Ilídio J
Format: Article
Language:English
Subjects:
Aluminum Oxide - chemistry
Aluminum Oxide - pharmacology
Animals
Bone Regeneration - drug effects
Bone Substitutes - chemical synthesis
Bone Substitutes - chemistry
Bone Substitutes - pharmacology
Cells, Cultured
Humans
Materials Testing
Mechanical Phenomena
Osteoblasts - drug effects
Osteoblasts - physiology
Rats
Rats, Wistar
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction. The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.
ISSN:2280-8000
2280-8000
DOI:10.5301/JABFM.2012.9264