Prevalence of Serum Antibody to Staphylococcal Enterotoxin F among Wisconsin Residents: Implications for Toxic-Shock Syndrome

Staphylococcal enterotoxin F (SEF) has previously been shown to be a marker for toxic-shock syndrome (TSS)-associated strains of Staphylococcus aureus, whereas the serologic absence of antibody to SEF (anti-SEF) has been shown to be a marker for susceptibility of persons to TSS. In this study, anti-...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-10, Vol.148 (4), p.692-698
Main Authors: Vergeront, J. M., Stolz, S. J., Crass, B. A., Nelson, D. B., Davis, J. P., Bergdoll, M. S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Age groups
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibodies
Antibodies, Bacterial - analysis
Bacterial Toxins
Biological and medical sciences
Child
Child, Preschool
Disease Susceptibility
Diseases
Emergency and intensive care: infection, septic shock
Enterotoxins
Enterotoxins - immunology
Epidemiology
Female
Humans
Infant
Intensive care medicine
Logistic regression
Male
Medical sciences
Menstrual hygiene products
Middle Aged
Radioimmunoassay
Regression Analysis
Risk
Shock, Septic - immunology
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - immunology
Superantigens
Toxicity
Wisconsin
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Summary:Staphylococcal enterotoxin F (SEF) has previously been shown to be a marker for toxic-shock syndrome (TSS)-associated strains of Staphylococcus aureus, whereas the serologic absence of antibody to SEF (anti-SEF) has been shown to be a marker for susceptibility of persons to TSS. In this study, anti-SEF was measured by radioimmunoassay in 689 banked sera obtained from Wisconsin residents during 1960, 1970, and 1980. The prevalence of anti-SEF as estimated by logistic regression analysis was 47%, 58%, 70%, 88%, 96%, and 99% at ages one, five, 10, 20, 30, and 50 years, respectively. Evidence for the transplacental transfer of anti-SEF is also presented. Despite the reported increased incidence of TSS occurring during the past five years, with a preponderance of cases occurring among women, no significant differences in the prevalence of anti-SEF were noted between sexes or longitudinally between the years 1960, 1970, and 1980. These data enhance our understanding of the epidemiology of TSS and further identify the population that may be susceptible to TSS.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/148.4.692