Synthesis, Spectroscopy and X-Ray Crystal Structure of 9-Methyl-3-Thiophen-2-Yl-Thieno [3, 2-e] [1, 2, 4] Triazolo [4, 3-c] Pyrimidine-8-Carboxylic Acid Ethyl Ester

The Preparation of 9-Methyl-3-thiophen-2-yl-thieno [3, 2-e] [1, 2, 4] triazolo [4, 3-c] pyrimi-dine-8-carboxylic acid ethyl ester is described. Elemental analysis, IR spectrum, super( 1)H NMR, super( 13)C NMR and X-ray crystal structure analyses were carried out to determine the composition and mole...

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Published in:American journal of analytical chemistry 2011-07, Vol.2 (3), p.371-375
Main Authors: Fathima, Nikhath, Ziaulla, Mohamed, Banu, Afshan, Panchamukhi, Shridhar Ishwar, Khazi, Imtiyaz Ahmed, Begum, Noor Shahina
Format: Article
Language:English
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Summary:The Preparation of 9-Methyl-3-thiophen-2-yl-thieno [3, 2-e] [1, 2, 4] triazolo [4, 3-c] pyrimi-dine-8-carboxylic acid ethyl ester is described. Elemental analysis, IR spectrum, super( 1)H NMR, super( 13)C NMR and X-ray crystal structure analyses were carried out to determine the composition and molecular structure of the title compound. There are two independent molecules in the asymmetric unit exhibiting intermolecular C-HN, C-HO interactions with additional pi - pi interaction that further helps in stabilizing the supramo-lecular structure. The results showed that the proposed method for synthesis is simple, precise and accurate which was further confirmed by crystal structure analysis.
ISSN:2156-8251
2156-8278
DOI:10.4236/ajac.2011.23045