Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens-Fresnel theorem

• Published in: Applied optics (2004) 2013-03, Vol.52 (8), p.1574-1580
• Main Authors: Avanaki, Mohammad R N, Podoleanu, Adrian Gh, Schofield, John B, Jones, Carole, Sira, Manu, Liu, Yan, Hojjat, Ali
• Format: Article
• Language: English
• Subjects: Algorithms; Dermoscopy - instrumentation; Dermoscopy - methods; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Light; Nephelometry and Turbidimetry - methods; Phantoms, Imaging; Scattering, Radiation; Skin - cytology; Tomography, Optical Coherence - instrumentation; Tomography, Optical Coherence - methods
• ISSN: 1559-128X; 2155-3165
• DOI: 10.1364/AO.52.001574

An optical properties extraction algorithm is developed based on enhanced Huygens-Fresnel light propagation theorem, to extract the scattering coefficient of a specific region in an optical coherence tomography (OCT) image. The aim is to quantitatively analyze the OCT images. The algorithm is evaluated using a set of phantoms with different concentrations of scatterers, designed based on Mie theory. The algorithm is then used to analyze basal cell carcinoma and healthy eyelid tissues, demonstrating distinguishable differences in the scattering coefficient between these tissues. In this study, we have taken advantage of the simplification introduced by the utilization of a dynamic focus OCT system. This eliminates the need to deconvolve the reflectivity profile with the confocal gate profile, as the sensitivity of the OCT system is constant throughout the axial range.