Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides

Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of pip...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 1991-06, Vol.21 (3), p.266-274
Main Authors: Ankley, Gerald T., Dierkes, Joseph R., Jensen, Douglas A., Peterson, Gregory S.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Crustacea - drug effects
Cytochrome P-450 Enzyme System - drug effects
Daphnia - drug effects
Dose-Response Relationship, Drug
Environmental pollutants toxicology
Insecticides - pharmacology
Medical sciences
Organophosphorus Compounds
Piperonyl Butoxide - pharmacology
Species Specificity
Toxicology
Toxicology - methods
Water
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Summary:Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures.
ISSN:0147-6513
1090-2414
DOI:10.1016/0147-6513(91)90065-W