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Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides
Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of pip...
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Published in: | Ecotoxicology and environmental safety 1991-06, Vol.21 (3), p.266-274 |
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cites | cdi_FETCH-LOGICAL-c418t-191e0d7fec504ff4129e088638ed0906bed23cc3c395aaadedd011111a84d1393 |
container_end_page | 274 |
container_issue | 3 |
container_start_page | 266 |
container_title | Ecotoxicology and environmental safety |
container_volume | 21 |
creator | Ankley, Gerald T. Dierkes, Joseph R. Jensen, Douglas A. Peterson, Gregory S. |
description | Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species:
Ceriodaphnia dubia, Daphnia magna, and
Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures. |
doi_str_mv | 10.1016/0147-6513(91)90065-W |
format | article |
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Ceriodaphnia dubia, Daphnia magna, and
Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/0147-6513(91)90065-W</identifier><identifier>PMID: 1868783</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Crustacea - drug effects ; Cytochrome P-450 Enzyme System - drug effects ; Daphnia - drug effects ; Dose-Response Relationship, Drug ; Environmental pollutants toxicology ; Insecticides - pharmacology ; Medical sciences ; Organophosphorus Compounds ; Piperonyl Butoxide - pharmacology ; Species Specificity ; Toxicology ; Toxicology - methods ; Water</subject><ispartof>Ecotoxicology and environmental safety, 1991-06, Vol.21 (3), p.266-274</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-191e0d7fec504ff4129e088638ed0906bed23cc3c395aaadedd011111a84d1393</citedby><cites>FETCH-LOGICAL-c418t-191e0d7fec504ff4129e088638ed0906bed23cc3c395aaadedd011111a84d1393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014765139190065W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3482,3549,27924,27925,45780,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19853549$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1868783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ankley, Gerald T.</creatorcontrib><creatorcontrib>Dierkes, Joseph R.</creatorcontrib><creatorcontrib>Jensen, Douglas A.</creatorcontrib><creatorcontrib>Peterson, Gregory S.</creatorcontrib><title>Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species:
Ceriodaphnia dubia, Daphnia magna, and
Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Crustacea - drug effects</subject><subject>Cytochrome P-450 Enzyme System - drug effects</subject><subject>Daphnia - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental pollutants toxicology</subject><subject>Insecticides - pharmacology</subject><subject>Medical sciences</subject><subject>Organophosphorus Compounds</subject><subject>Piperonyl Butoxide - pharmacology</subject><subject>Species Specificity</subject><subject>Toxicology</subject><subject>Toxicology - methods</subject><subject>Water</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi1EVbaFfwCSL6ByCHhiJ2tfKqGKL6lSOYB6NLP2pGuUjVM7Afrv67Areutc5vB-aOZh7CWIdyCgfS9Arau2AXlm4K0Rom2q6ydsBcKIqlagnrLVf8szdpLzLyGEFE1zzI5Bt3qt5Yr9_BZGSnG46_lmnuLf4Ilj5sinGHseBo63M07B8UVzsY83wWHPE2XC5Lb8T5i2PKYbHOK4jXnc4kQllsmVUCnLz9lRh32mF4d9yn58-vj94kt1efX568WHy8op0FMFBkj4dUeuEarrFNSGhNat1OTLQ-2GfC2dk06aBhE9eS9gGdTKgzTylL3Z944p3s6UJ7sL2VHf40Bxzhbkum51DcWo9kaXYs6JOjumsMN0Z0HYBaxdqNmFmjVg_4G11yX26tA_b3bkH0J7kkV_fdAxF0JdwsGF_GAzupGNWu483_uowPgdKNnsAg2OfEgFmvUxPH7IPVk9llg</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>Ankley, Gerald T.</creator><creator>Dierkes, Joseph R.</creator><creator>Jensen, Douglas A.</creator><creator>Peterson, Gregory S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope></search><sort><creationdate>19910601</creationdate><title>Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides</title><author>Ankley, Gerald T. ; Dierkes, Joseph R. ; Jensen, Douglas A. ; Peterson, Gregory S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-191e0d7fec504ff4129e088638ed0906bed23cc3c395aaadedd011111a84d1393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Crustacea - drug effects</topic><topic>Cytochrome P-450 Enzyme System - drug effects</topic><topic>Daphnia - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental pollutants toxicology</topic><topic>Insecticides - pharmacology</topic><topic>Medical sciences</topic><topic>Organophosphorus Compounds</topic><topic>Piperonyl Butoxide - pharmacology</topic><topic>Species Specificity</topic><topic>Toxicology</topic><topic>Toxicology - methods</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ankley, Gerald T.</creatorcontrib><creatorcontrib>Dierkes, Joseph R.</creatorcontrib><creatorcontrib>Jensen, Douglas A.</creatorcontrib><creatorcontrib>Peterson, Gregory S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ankley, Gerald T.</au><au>Dierkes, Joseph R.</au><au>Jensen, Douglas A.</au><au>Peterson, Gregory S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>21</volume><issue>3</issue><spage>266</spage><epage>274</epage><pages>266-274</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxyphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species:
Ceriodaphnia dubia, Daphnia magna, and
Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1868783</pmid><doi>10.1016/0147-6513(91)90065-W</doi><tpages>9</tpages></addata></record> |
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language | eng |
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source | ScienceDirect; Backfile Package - Environmental Science (Legacy) [YES] |
subjects | Animals Biological and medical sciences Crustacea - drug effects Cytochrome P-450 Enzyme System - drug effects Daphnia - drug effects Dose-Response Relationship, Drug Environmental pollutants toxicology Insecticides - pharmacology Medical sciences Organophosphorus Compounds Piperonyl Butoxide - pharmacology Species Specificity Toxicology Toxicology - methods Water |
title | Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides |
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