Paper-Based SlipPAD for High-Throughput Chemical Sensing

We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed sensing while maintaining the extreme simplicity of paper-based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one lay...

Full description

Saved in:
Bibliographic Details
Published in:Analytical chemistry (Washington) 2013-05, Vol.85 (9), p.4263-4267
Main Authors: Liu, Hong, Li, Xiang, Crooks, Richard M
Format: Article
Language:English
Subjects:
Analytical chemistry
Bioassays
Colorimetry
Fluorescence
High-Throughput Screening Assays - instrumentation
Microfluidic Analytical Techniques - instrumentation
Sensors
Spectrometry, Fluorescence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed sensing while maintaining the extreme simplicity of paper-based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one layer relative to the other, solutions wick simultaneously into a large array of sensing reservoirs or sequentially into a large array of channels to carry out homogeneous or heterogeneous assays, respectively. The applicability of the device to high-throughput multiplex chemical analysis is demonstrated by colorimetric and fluorescent assays.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac4008623