Increased VEGFR-1 immunoreactivity in the choroid-scleral complex in hypercholesterolemia experimental model

The aim of this study is to investigate the expression of vascular endothelial growth factor (VEGF) in the choroid and sclera using hypercholesterolemia experimental model. New Zealand rabbits were divided into two groups: 8 rabbits (8 eyes), in the normal diet group (NG), were fed by a standard die...

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Published in:Arquivos brasileiros de oftalmologia 2013-01, Vol.76 (1), p.1-5
Main Authors: Torres, Rogil José de Almeida, Noronha, Lucia de, Casella, Antonio Marcelo Barbante, Torres, Regiane do Rocio de Almeida, Martins, Isabela de Carvalho, Zotz, Rafael, Luchini, Andréa, Hoffmann Filho, Conrado Roberto, Précoma, Dalton Bertolim
Format: Article
Language:Portuguese
Subjects:
Animals
Cholesterol, Dietary - adverse effects
Choroid - metabolism
Choroid - pathology
Disease Models, Animal
Humans
Hypercholesterolemia - etiology
Hypercholesterolemia - metabolism
Hypercholesterolemia - pathology
Male
Rabbits
Sclera - metabolism
Sclera - pathology
Vascular Endothelial Growth Factor Receptor-1 - metabolism
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Summary:The aim of this study is to investigate the expression of vascular endothelial growth factor (VEGF) in the choroid and sclera using hypercholesterolemia experimental model. New Zealand rabbits were divided into two groups: 8 rabbits (8 eyes), in the normal diet group (NG), were fed by a standard diet for 4 weeks; and 13 rabbits (13 eyes), in the hypercholesterolemic group (HG), were fed by a 1% cholesterol-enriched diet for 8 weeks. Total serum cholesterol, triglyceride, HDL cholesterol and fasting blood glucose exams were performed at the initiation of the experiment and at the euthanasia time. After hypercholesterolemic group 8th week and NG 4th week, animals were euthanized and their eyes underwent immunohistochemical analysis with the RAM-11 and VEGFR-1). The diet has induced a significant increase in total cholesterol and triglyceride levels in HG when compared with NG (p
ISSN:1678-2925