Ultrasound-guided radiofrequency ablation of early breast cancer in a resection specimen: Lessons for further research

Abstract Purpose To assess the feasibility and effectiveness of radiofrequency ablation (RFA) in breast cancer, using different histopathologic staining methods to evaluate tissue viability. Materials and methods In twenty patients with unifocal small (≤1, 5 cm) invasive ductal carcinoma, ultrasound...

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Bibliographic Details
Published in:Breast (Edinburgh) 2013-08, Vol.22 (4), p.543-547
Main Authors: Kreb, D.L, Looij, B.G, Ernst, M.F, Rutten, M.J.C.M, Jager, G.J, van der Linden, J.C, Pruijt, J.F.M, Bosscha, K
Format: Article
Language:English
Subjects:
Aged
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - surgery
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - surgery
Catheter Ablation - methods
Cell Survival
Cytokeratin 8
Feasibility Studies
Female
Hematology, Oncology and Palliative Medicine
Humans
In Vitro Techniques
Mastectomy
Mastectomy, Segmental
Middle Aged
Minimally invasive techniques
Nicotinamide adenine dinucleotide diaphorase
Radiofrequency ablation
Surgery, Computer-Assisted - methods
Treatment Outcome
Ultrasonography, Interventional - methods
Ultrasonography, Mammary - methods
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Summary:Abstract Purpose To assess the feasibility and effectiveness of radiofrequency ablation (RFA) in breast cancer, using different histopathologic staining methods to evaluate tissue viability. Materials and methods In twenty patients with unifocal small (≤1, 5 cm) invasive ductal carcinoma, ultrasound-guided RFA was performed immediately after surgery. Cell viability was assessed using cytokeratin 8 (CK 8) and nicotinamide adenine dinucleotide diaphorase (NADHD) in addition to hematoxylin–eosin (HE). Results At histopathological examination, ex vivo RFA resulted in complete cell death of the target lesion in 17/20 patients. In two cases viable ductal carcinoma in situ (DCIS) was found just outside the completely ablated lesion. Conclusion RFA of small invasive breast cancer seems to be a feasible treatment option. Both NADHD and CK 8 demonstrate a clear and comparable demarcation between viable and non-viable tissue. A high level of accuracy is required in proper positioning of the needle electrode and a “hot retraction” is mandatory.
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2012.11.004