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Surfactant Protein-A Concentration in Sera from Dogs with Pulmonary Parenchymal Diseases

Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmo...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2013, Vol.75(6), pp.685-691
Main Authors: SONE, Katsuhito, AKIYOSHI, Hideo, SHIMIZU, Junichiro, CAO, Zheng, LI, Yijyun, TANAKA, Toshiyuki, HAYASHI, Akiyoshi, SUGII, Shunji, OHASHI, Fumihito
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Language:English
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Summary:Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmonary parenchymal diseases in dogs. Thirty-two dogs with pulmonary parenchymal diseases, 34 with nonrespiratory diseases and 57 healthy dogs were included. Serum SP-A concentration was measured in all dogs using sandwich enzyme linked immunosorbent assay with an anti-dog SP-A polyclonal antibody. Median serum SP-A concentration in healthy dogs was
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.12-0255