Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder

Abstract Objective A role for childhood adversity in the development of numerous medical conditions in adults has been described in the general population, but has not been examined in patients with bipolar disorder who have multiple medical comorbidities which contribute to their premature mortalit...

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Bibliographic Details
Published in:Journal of affective disorders 2013-05, Vol.147 (1), p.288-294
Main Authors: Post, Robert M, Altshuler, Lori L, Leverich, Gabriele S, Frye, Mark A, Suppes, Trisha, McElroy, Susan L, Keck, Paul E, Nolen, Willem A, Kupka, Ralph W, Grunze, Heinz, Rowe, Mike
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Adversity
Affective disorders
Biological and medical sciences
Bipolar affective disorder
Bipolar Disorder - epidemiology
Bipolar Disorder - etiology
Bipolar disorders
Child
Child Abuse
Childhood
Childhood adversity
Comorbidity
Female
Humans
Male
Medical conditions
Medical illness
Medical sciences
Metabolic diseases
Middle Aged
Mood disorders
Obesity
Parents
Physical and sexual abuse
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychosocial stress
Surveys and Questionnaires
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Summary:Abstract Objective A role for childhood adversity in the development of numerous medical conditions in adults has been described in the general population, but has not been examined in patients with bipolar disorder who have multiple medical comorbidities which contribute to their premature mortality. Methods More than 900 outpatients (average age 41) with bipolar disorder completed questionnaires that included information about the occurrence of verbal, physical, or sexual abuse in childhood and whether their parents had a mood or substance abuse disorder, or a history of suicidality. These factors were combined to form a total childhood adversity score, which was then related to one or more of 30 medical conditions patients rated as present or absent. Results The child adversity score was significantly related to the total number of medical comorbidities a patient had ( p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2012.11.020