Immunomodulating activity of thymosin fraction 5 and thymosin alpha sub(1) in immunosuppressed mice

The authors found that both thymosin from calf thymus and its constituent peptide alpha sub(1) prepared by chemical synthesis restore cell-mediated immunity following its suppression in mice by injection of 5-FU. Conditions suitable for assessing the thymosin activity by means of footpad reaction we...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 1983-01, Vol.15 (2), p.108-113
Main Authors: Ohta, Y, Sueki, K, Yoneyama, Y, Tezuka, E, Yagi, Y
Format: Article
Language:English
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Summary:The authors found that both thymosin from calf thymus and its constituent peptide alpha sub(1) prepared by chemical synthesis restore cell-mediated immunity following its suppression in mice by injection of 5-FU. Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice. In this new animal model, thymosin alpha sub(1)-peptide showed activity at a low dose of 5-50 mu g/kg, which was 100-1,000 times less than that required for thymosin F-5 preparations. All the results indicate that thymosin alpha sub(1) accelerates the replenishment and maturation of haematopoietic cells, including not only T cells but also macrophages, when they have been severely damaged by the 5-FU treatment.
ISSN:0340-7004