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Immunomodulating activity of thymosin fraction 5 and thymosin alpha sub(1) in immunosuppressed mice
The authors found that both thymosin from calf thymus and its constituent peptide alpha sub(1) prepared by chemical synthesis restore cell-mediated immunity following its suppression in mice by injection of 5-FU. Conditions suitable for assessing the thymosin activity by means of footpad reaction we...
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| Published in: | Cancer Immunology, Immunotherapy Immunotherapy, 1983-01, Vol.15 (2), p.108-113 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 113 |
| container_issue | 2 |
| container_start_page | 108 |
| container_title | Cancer Immunology, Immunotherapy |
| container_volume | 15 |
| creator | Ohta, Y Sueki, K Yoneyama, Y Tezuka, E Yagi, Y |
| description | The authors found that both thymosin from calf thymus and its constituent peptide alpha sub(1) prepared by chemical synthesis restore cell-mediated immunity following its suppression in mice by injection of 5-FU. Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice. In this new animal model, thymosin alpha sub(1)-peptide showed activity at a low dose of 5-50 mu g/kg, which was 100-1,000 times less than that required for thymosin F-5 preparations. All the results indicate that thymosin alpha sub(1) accelerates the replenishment and maturation of haematopoietic cells, including not only T cells but also macrophages, when they have been severely damaged by the 5-FU treatment. |
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| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology, Immunotherapy, 1983-01, Vol.15 (2), p.108-113 |
| issn | 0340-7004 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13747257 |
| source | Open Access: PubMed Central; Springer Online Journal Archives |
| title | Immunomodulating activity of thymosin fraction 5 and thymosin alpha sub(1) in immunosuppressed mice |
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