Electrogenic ion transport and bioelectric excitation, a quantitative theory of their relationship: Part II. Voltage clamp currents of the first generation equations

The equations of the preceding paper are amended to represent voltage clamp instead of an action potential, but without altering the value of any constant. Calculated membrane current densities resemble observed membrane current densities of living, electrically excitable, voltage clamped preparatio...

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Bibliographic Details
Published in:Bioelectrochemistry and Bioenergetics 1983, Vol.10 (1), p.109-118
Main Authors: Lowenhaupt, Benjamin, Gifford, Peter K., Astbury, Jeffrey C.
Format: Article
Language:English
Subjects:
electrons
membrane currents
sodium
Online Access:Get full text
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Summary:The equations of the preceding paper are amended to represent voltage clamp instead of an action potential, but without altering the value of any constant. Calculated membrane current densities resemble observed membrane current densities of living, electrically excitable, voltage clamped preparations. The calculated and observed currents are not quite identical, however, and the discussion considers possible explanations for the differences. The calculated sodium current density turns out to be too small to account for the transitory inward current of a depolarizing voltage clamp step. Instead, this inward current is mostly electron current. However, there is electron current in the reverse direction subsequently, and the net electron current is zero if the beginning and ending states of the excitable membrane are the same.
ISSN:0302-4598
DOI:10.1016/0302-4598(83)80109-3