Relationship of clinical findings in systemic lupus erythematosus to seroreactivity

We have characterized 52 consecutive patients fulfilling 4 or more of the American Rheumatism Association criteria for systemic lupus erythematosus in order to provide, for the first time, a homogeneous sample for statistical comparison of antinuclear antibody (ANA)‐positive and ANA‐negative groups....

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Bibliographic Details
Published in:Arthritis and rheumatism 1983-01, Vol.26 (1), p.45-51
Main Authors: Rothschild, Bruce M., Jones, John Verrier, Chesney, Carolyn, David Pifer, D., Thompson, Lee D., James, Karen K., Badger, Harriette
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antinuclear - analysis
Antigen-Antibody Complex - analysis
Blood Sedimentation
Complement C3 - analysis
Complement C3c
Complement C4 - analysis
DNA - immunology
Female
Humans
Lupus Erythematosus, Systemic - immunology
Male
Rheumatoid Factor - analysis
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Summary:We have characterized 52 consecutive patients fulfilling 4 or more of the American Rheumatism Association criteria for systemic lupus erythematosus in order to provide, for the first time, a homogeneous sample for statistical comparison of antinuclear antibody (ANA)‐positive and ANA‐negative groups. Ten patients (19%) were seronegative. There was no significant difference in age, disease activity, organ system involvement, erythrocyte sedimentation rate, immune complex levels, or C3 levels. The ANA‐negative group showed a higher incidence of involvement for whites and men. Leukopenia, lower levels of antibody to DNA, and higher C4 levels were also characteristic of the ANA‐negative group.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780260108