Alpha-amanitin tolerance in mycophagous Drosophila

Six species of Drosophila were tested for tolerance to the mushroom toxin α-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species--D. melanogaster, D. immigrans, and D. pseudoobscura--showed very low survival and long development times in the presence of amanitin. Three myc...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-01, Vol.221 (4606), p.165-167
Main Authors: Jaenike, J, Grimaldi, D.A, Sluder, A.E, Greenleaf, A.L
Format: Article
Language:English
Subjects:
Amanitins
animal physiology
arthropods
Biological taxonomies
Body size
Drosophila
Drosophilidae
entomology
Female animals
Insect larvae
Male animals
Mushrooms
Mycology
RNA
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Summary:Six species of Drosophila were tested for tolerance to the mushroom toxin α-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species--D. melanogaster, D. immigrans, and D. pseudoobscura--showed very low survival and long development times in the presence of amanitin. Three mycophagous species--D. putrida, D. recens, and D. tripunctata--showed little or no sensitivity. Analysis in vitro indicated that this tolerance is not based on alteration of the molecular structure of RNA polymerase II.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.221.4606.165