Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D sub(3) metabolites

The authors report here that 1,25-(OH) sub(2)D sub(3) had a biphasic effect on the replication of two distinct human cancer cell lines, i.e., the breast cancer T-47D and the malignant melanoma MM96, and effect analogous to that of estrogens on the breast cancer cell line MCF-7. These inhibitory effe...

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Published in:Cancer research (Chicago, Ill.) Ill.), 1983-01, Vol.43 (9), p.4443-4447
Main Authors: Frampton, R J, Omond, SA, Eisman, JA
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Omond, SA
Eisman, JA
description The authors report here that 1,25-(OH) sub(2)D sub(3) had a biphasic effect on the replication of two distinct human cancer cell lines, i.e., the breast cancer T-47D and the malignant melanoma MM96, and effect analogous to that of estrogens on the breast cancer cell line MCF-7. These inhibitory effects were accompanied by marked morphological changes. Furthermore, two known metabolites of 1,25-(OH) sub(2)D sub(3), i.e., 1,24,25-trihydroxyvitamin D sub(3) and 1,25,26-trihydroxyvitamin D sub(3), which compete for binding to the 1,25-(OH) sub(2)D sub(3) receptor, did not stimulate but were almost equipotent with 1,25-(OH) sub(2)D sub(3) in inhibiting the replication of both cell lines. These 1,25-dihydroxyvitamin D sub(3) metabolites show promise for the inhibition of cancer growth, analogous to the effect of estrogens and antiestrogens in breast cancer but with potential application in a much wider range of human cancers.
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title Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D sub(3) metabolites
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