IFPA Gabor Than Award lecture: Molecular control of placental growth: The emerging role of microRNAs

Abstract Fetal growth is dependent on appropriate growth and function of the placenta. This is modulated by a variety of factors, including maternal growth factors that exert their actions by binding to specific receptors on trophoblast to promote activation of signaling events. Kinases and phosphat...

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Bibliographic Details
Published in:Placenta 2013-03, Vol.34, p.S27-S33
Main Author: Forbes, K
Format: Article
Language:English
Subjects:
Awards and Prizes
Biological and medical sciences
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - drug effects
Humans
IGF
Intercellular Signaling Peptides and Proteins - pharmacology
Intercellular Signaling Peptides and Proteins - physiology
Internal Medicine
MicroRNAs - physiology
miRNA
Obstetrics and Gynecology
Placenta - metabolism
Placentation - drug effects
Placentation - genetics
Pregnancy
Pregnancy. Parturition. Lactation
Proliferation
Signal Transduction - drug effects
Signal Transduction - genetics
Vertebrates: reproduction
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Summary:Abstract Fetal growth is dependent on appropriate growth and function of the placenta. This is modulated by a variety of factors, including maternal growth factors that exert their actions by binding to specific receptors on trophoblast to promote activation of signaling events. Kinases and phosphatases within trophoblast act in concert to regulate growth factor actions and recent studies have begun to elucidate a role for microRNAs (miRs) in regulating the levels of these proteins in the placenta. This review will discuss growth factor signaling in the placenta and describe the emerging role of miRs in regulating placental development.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2012.12.011