Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression

Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of C...

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Bibliographic Details
Published in:Cancer letters 2013-08, Vol.336 (2), p.281-289
Main Authors: Chen, Zhao, Pan, Xueke, Georgakilas, Alexandros G, Chen, Pei, Hu, Huan, Yang, Ying, Tian, Sijia, Xia, Lei, Zhang, Jing, Cai, Xiaoxiao, Ge, Jian, Yu, Keming, Zhuang, Jing
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Apoptosis - drug effects
Blood-brain barrier
Brain Neoplasms - drug therapy
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Brain Neoplasms - prevention & control
C6 glioma cells
Calcium - metabolism
Cancer therapies
Cell adhesion & migration
Cell Line, Tumor
Cell Movement - drug effects
Chemokine CXCL12 - biosynthesis
Chemokines
Chemotherapy
CXCR4
Down-Regulation - drug effects
Free radicals
Glioma - drug therapy
Glioma - metabolism
Glioma - pathology
Glioma - prevention & control
Hematology, Oncology and Palliative Medicine
Hydrogen Peroxide - antagonists & inhibitors
Hydrogen Peroxide - pharmacology
Hypotheses
Hypoxia
Immune system
Ischemia
Lung cancer
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Neurotoxicity
Pyrazines - pharmacology
Rat cerebral neurocytes
Rats
Receptors, CXCR4 - antagonists & inhibitors
Receptors, CXCR4 - biosynthesis
Receptors, CXCR4 - genetics
Tetramethylpyrazine (TMP)
Tumors
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Summary:Highlights • TMP effectively inhibits the rise of [Ca2+]i in cerebral neurocytes. • TMP effectively inhibits glutamate releasing in cerebral neurocytes. • TMP significantly decreases the migration and proliferation of C6 glioma cells. • TMP-mediated suppression of C6 gliomas involves inhibition of CXCR4 expression. • TMP-mediated neural protection involves inhibition of CXCR4 expression.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.03.015