Energy balance regulation by thyroid hormones at central level

Highlights • Thyroid hormones regulate energy balance and metabolism by acting at the central level. • Thyroid hormones modulate the autonomous nervous system. • Thyroid hormones modulate hypothalamic UCP2 and mTOR to regulate feeding. • Thyroid hormones modulate hypothalamic AMPK to regulate thermo...

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Bibliographic Details
Published in:Trends in molecular medicine 2013-07, Vol.19 (7), p.418-427
Main Authors: López, Miguel, Alvarez, Clara V, Nogueiras, Rubén, Diéguez, Carlos
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - metabolism
Animals
central nervous system
Eating - physiology
energy balance
Energy Metabolism - physiology
Glucose - metabolism
glucose homeostasis
Homeostasis
Humans
hypothalamus
lipid metabolism
Liver - metabolism
Pathology
Thermogenesis - physiology
thyroid hormones
Thyroid Hormones - physiology
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Summary:Highlights • Thyroid hormones regulate energy balance and metabolism by acting at the central level. • Thyroid hormones modulate the autonomous nervous system. • Thyroid hormones modulate hypothalamic UCP2 and mTOR to regulate feeding. • Thyroid hormones modulate hypothalamic AMPK to regulate thermogenesis in brown adipose tissue. • Thyroid hormones act on the hypothalamus to regulate hepatic glucose metabolism.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2013.04.004