Expression of the major neurofilament subunit in chicken erythrocytes

The 70,000-dalton core polypeptide of neurofilaments, though to exist only in neurons, has been detected in chicken erythrocytes, where it coexists with vimentin and synemin as a component of the intermediate filament network. It is present in the circulating erythroid cells of embryos and young chi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983, Vol.217 (4610), p.553-556
Main Authors: Granger, B.L, Lazarides, E
Format: Article
Language:English
Subjects:
animal physiology
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Summary:The 70,000-dalton core polypeptide of neurofilaments, though to exist only in neurons, has been detected in chicken erythrocytes, where it coexists with vimentin and synemin as a component of the intermediate filament network. It is present in the circulating erythroid cells of embryos and young chickens but is nearly absent from the erythroid cells of adults. These findings are inconsistent with current models of intermediate filaments expression, but provide another example of unexpected similarities between the nervous and hemopoietic systems.
ISSN:0036-8075
1095-9203