Isolation, Structure, and Synthesis of a Human Seminal Plasma Peptide with Inhibin-Like Activity

A basic peptide isolated from pooled human seminal plasma exhibited inhibin-like activity by suppressing pituitary follicle-stimulating hormone secretion in vitro and in vivo. The peptide has been characterized and sequenced, and a 31-amino-acid synthetic replicate showed full biological activity in...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-03, Vol.223 (4641), p.1199-1202
Main Authors: Ramasharma, K., Sairam, M. R., Seidah, N. G., Chrétien, M., Manjunath, P., Schiller, P. W., Yamashiro, D., Li, Choh Hao
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Amino Acids - analysis
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Chromatography
Endocrinology, Experimental
Follicle Stimulating Hormone - metabolism
Fundamental and applied biological sciences. Psychology
Gels
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gonadotropins
Hormone research
Hormones
Humans
inhibin
Inhibins - isolation & purification
Inhibins - pharmacology
Luteinizing Hormone - metabolism
Male
man
Mice
Molecular Weight
peptides
Peptides - chemical synthesis
Peptides - isolation & purification
Pituitary Gland - metabolism
Prostatic Secretory Proteins
Proteins
Proteins - chemical synthesis
Proteins - isolation & purification
Proteins - pharmacology
Radioligand assay
Rats
Secretion
Semen - analysis
seminal fluid
Seminal plasma
Seminal Plasma Proteins
Subcutaneous injections
Yeasts
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Summary:A basic peptide isolated from pooled human seminal plasma exhibited inhibin-like activity by suppressing pituitary follicle-stimulating hormone secretion in vitro and in vivo. The peptide has been characterized and sequenced, and a 31-amino-acid synthetic replicate showed full biological activity in vitro.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6422553