Lead poisoning in monkeys during pregnancy and lactation

Twenty-two female monkeys ( Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation. A high dose of lead (5 mg Pb 2+/kg/day) can induce abortions and death in pregnant monkeys. At a lower dose (1 mg Pb 2+/kg/day), the foetus can be exposed to lead via placent...

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Bibliographic Details
Published in:The Science of the total environment 1983-01, Vol.30, p.221-229
Main Authors: Tachon, P., Laschi, A., Briffaux, J.P., Brain, G., Chambon, P.
Format: Article
Language:English
Subjects:
Air
Animals
Animals, Newborn - metabolism
Animals, Newborn - physiology
Biological and medical sciences
Environmental pollutants toxicology
Female
Fetus - metabolism
Fetus - pathology
Lactation
Lead - analysis
Lead - metabolism
Lead Poisoning - metabolism
Lead Poisoning - pathology
Macaca
Medical sciences
Milk, Human - analysis
Pregnancy
Pregnancy Complications - metabolism
Pregnancy Complications - pathology
Tissue Distribution
Toxicology
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Summary:Twenty-two female monkeys ( Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation. A high dose of lead (5 mg Pb 2+/kg/day) can induce abortions and death in pregnant monkeys. At a lower dose (1 mg Pb 2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth.
ISSN:0048-9697
1879-1026
DOI:10.1016/0048-9697(83)90014-1