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Lead poisoning in monkeys during pregnancy and lactation
Twenty-two female monkeys ( Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation. A high dose of lead (5 mg Pb 2+/kg/day) can induce abortions and death in pregnant monkeys. At a lower dose (1 mg Pb 2+/kg/day), the foetus can be exposed to lead via placent...
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| Published in: | The Science of the total environment 1983-01, Vol.30, p.221-229 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c417t-292de56ff9645d54c331453d25a3664f6f162badf0f9dc1f3de25be32dabaf973 |
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| cites | cdi_FETCH-LOGICAL-c417t-292de56ff9645d54c331453d25a3664f6f162badf0f9dc1f3de25be32dabaf973 |
| container_end_page | 229 |
| container_issue | |
| container_start_page | 221 |
| container_title | The Science of the total environment |
| container_volume | 30 |
| creator | Tachon, P. Laschi, A. Briffaux, J.P. Brain, G. Chambon, P. |
| description | Twenty-two female monkeys (
Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation.
A high dose of lead (5 mg Pb
2+/kg/day) can induce abortions and death in pregnant monkeys.
At a lower dose (1 mg Pb
2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth. |
| doi_str_mv | 10.1016/0048-9697(83)90014-1 |
| format | article |
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Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation.
A high dose of lead (5 mg Pb
2+/kg/day) can induce abortions and death in pregnant monkeys.
At a lower dose (1 mg Pb
2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/0048-9697(83)90014-1</identifier><identifier>PMID: 6648509</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Air ; Animals ; Animals, Newborn - metabolism ; Animals, Newborn - physiology ; Biological and medical sciences ; Environmental pollutants toxicology ; Female ; Fetus - metabolism ; Fetus - pathology ; Lactation ; Lead - analysis ; Lead - metabolism ; Lead Poisoning - metabolism ; Lead Poisoning - pathology ; Macaca ; Medical sciences ; Milk, Human - analysis ; Pregnancy ; Pregnancy Complications - metabolism ; Pregnancy Complications - pathology ; Tissue Distribution ; Toxicology</subject><ispartof>The Science of the total environment, 1983-01, Vol.30, p.221-229</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-292de56ff9645d54c331453d25a3664f6f162badf0f9dc1f3de25be32dabaf973</citedby><cites>FETCH-LOGICAL-c417t-292de56ff9645d54c331453d25a3664f6f162badf0f9dc1f3de25be32dabaf973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0048969783900141$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3481,27923,27924,45992</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9339895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6648509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tachon, P.</creatorcontrib><creatorcontrib>Laschi, A.</creatorcontrib><creatorcontrib>Briffaux, J.P.</creatorcontrib><creatorcontrib>Brain, G.</creatorcontrib><creatorcontrib>Chambon, P.</creatorcontrib><title>Lead poisoning in monkeys during pregnancy and lactation</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Twenty-two female monkeys (
Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation.
A high dose of lead (5 mg Pb
2+/kg/day) can induce abortions and death in pregnant monkeys.
At a lower dose (1 mg Pb
2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth.</description><subject>Air</subject><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fetus - pathology</subject><subject>Lactation</subject><subject>Lead - analysis</subject><subject>Lead - metabolism</subject><subject>Lead Poisoning - metabolism</subject><subject>Lead Poisoning - pathology</subject><subject>Macaca</subject><subject>Medical sciences</subject><subject>Milk, Human - analysis</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - metabolism</subject><subject>Pregnancy Complications - pathology</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWnaNLkIsvgFC170HNJkskTbdE1aYf-9rVv26FwGZp4ZXh6Ezgm-JZiwO4xzngomymtObwTGJE_JAZoTXoqU4IwdovkeOUYnMX7ioUpOZmjGWM4LLOaIr0CZZNO62Hrn14nzSdP6L9jGxPRhnGwCrL3yepsob5Ja6U51rvWn6MiqOsLZ1Bfo4-nxffmSrt6eX5cPq1TnpOzSTGQGCmatYHlhilxTSvKCmqxQdAhhmSUsq5Sx2AqjiaUGsqICmhlVKStKukBXu7-b0H73EDvZuKihrpWHto-SUM5xSfEA5jtQhzbGAFZugmtU2EqC5ShMjjbkaENyKv-EDdcLdDH976sGzP5oMjTsL6e9ilrVNgwqXNxjglLBRTFg9zsMBhc_DoKM2oHXYFwA3UnTuv9z_AKIJ4aS</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Tachon, P.</creator><creator>Laschi, A.</creator><creator>Briffaux, J.P.</creator><creator>Brain, G.</creator><creator>Chambon, P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19830101</creationdate><title>Lead poisoning in monkeys during pregnancy and lactation</title><author>Tachon, P. ; Laschi, A. ; Briffaux, J.P. ; Brain, G. ; Chambon, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-292de56ff9645d54c331453d25a3664f6f162badf0f9dc1f3de25be32dabaf973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Air</topic><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Animals, Newborn - physiology</topic><topic>Biological and medical sciences</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Fetus - pathology</topic><topic>Lactation</topic><topic>Lead - analysis</topic><topic>Lead - metabolism</topic><topic>Lead Poisoning - metabolism</topic><topic>Lead Poisoning - pathology</topic><topic>Macaca</topic><topic>Medical sciences</topic><topic>Milk, Human - analysis</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - metabolism</topic><topic>Pregnancy Complications - pathology</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tachon, P.</creatorcontrib><creatorcontrib>Laschi, A.</creatorcontrib><creatorcontrib>Briffaux, J.P.</creatorcontrib><creatorcontrib>Brain, G.</creatorcontrib><creatorcontrib>Chambon, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tachon, P.</au><au>Laschi, A.</au><au>Briffaux, J.P.</au><au>Brain, G.</au><au>Chambon, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lead poisoning in monkeys during pregnancy and lactation</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>30</volume><spage>221</spage><epage>229</epage><pages>221-229</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>Twenty-two female monkeys (
Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation.
A high dose of lead (5 mg Pb
2+/kg/day) can induce abortions and death in pregnant monkeys.
At a lower dose (1 mg Pb
2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>6648509</pmid><doi>10.1016/0048-9697(83)90014-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-9697 |
| ispartof | The Science of the total environment, 1983-01, Vol.30, p.221-229 |
| issn | 0048-9697 1879-1026 |
| language | eng |
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| source | Backfile Package - Environmental Science (Legacy) [YES] |
| subjects | Air Animals Animals, Newborn - metabolism Animals, Newborn - physiology Biological and medical sciences Environmental pollutants toxicology Female Fetus - metabolism Fetus - pathology Lactation Lead - analysis Lead - metabolism Lead Poisoning - metabolism Lead Poisoning - pathology Macaca Medical sciences Milk, Human - analysis Pregnancy Pregnancy Complications - metabolism Pregnancy Complications - pathology Tissue Distribution Toxicology |
| title | Lead poisoning in monkeys during pregnancy and lactation |
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