Detection of exposure to mutagenic compounds in low-tar and medium-tar cigarette smokers

A volunteer study was carried out on groups smoking low-tar (5.4 mg/cig.) and mediumtar (16.3 mg/cig.) cigarettes and on non-smokers. The number of cigarettes smoked was recorded daily throughout a 51-day study period, and the effects of smoking were measured in the beginning and after 3-week terms...

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Bibliographic Details
Published in:Environmental research 1984-01, Vol.33 (2), p.312-321
Main Authors: Sorsa, Marja, Falck, Kai, Heinonen, Tuula, Vainio, Harri, Norppa, Hannu, Rimpelä, Matti
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carboxyhemoglobin - analysis
Chemical mutagenesis
Humans
Male
Medical sciences
Mutagenicity Tests
Mutagens - urine
Sister Chromatid Exchange
Smoking
Sulfides - urine
Toxicology
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Summary:A volunteer study was carried out on groups smoking low-tar (5.4 mg/cig.) and mediumtar (16.3 mg/cig.) cigarettes and on non-smokers. The number of cigarettes smoked was recorded daily throughout a 51-day study period, and the effects of smoking were measured in the beginning and after 3-week terms of smoking medium-tar or low-tar cigarettes. The parameters measured were blood carboxyhemoglobin concentration, thioethers excreted into the urine, mutagenic activity in the urine, and the frequency of sister-chromatid exchanges in blood lymphoyctes. For all four parameters, the differences between the smokers and the non-smokers were significant. However, within the study design no differences could be detected between low-tar or medium-tar cigarette smoking in the biological-monitoring tests used.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(84)90029-X