The effect of antibiotic treatment on the in vivo selection of resistant haemolytic Escherichia coli clones in mice

The appearance of resistant haemolytic Escherichia coli clones was studied in mice treated with a synergistic combination of antibiotics. The R plasmid donor and the haemolytic recipient were given orally. Ten animals were treated i.p. with 2.5 mg carbenicillin and 2.5 mg kanamycin pro die for 7 day...

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Bibliographic Details
Published in:FEMS microbiology letters 1984-05, Vol.22 (3), p.179-182
Main Authors: Emody, Levente, Kerényi, Monika, Bátai, István
Format: Article
Language:English
Subjects:
Antibacterial agents
antibiotic treatment
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Escherichia coli
excretion of recombinants
haemolysin
in vivo selection
Medical sciences
Pharmacology. Drug treatments
R plasmid transfer
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Summary:The appearance of resistant haemolytic Escherichia coli clones was studied in mice treated with a synergistic combination of antibiotics. The R plasmid donor and the haemolytic recipient were given orally. Ten animals were treated i.p. with 2.5 mg carbenicillin and 2.5 mg kanamycin pro die for 7 days. Ten control mice were injected with saline. Out of 80 faecal samples of animals receiving antibiotic treatment resistant haemolytic transconjugants were isolated from 13 samples by direct plating, and from 27 samples after selective enrichment. Out of 80 parallel samples of control animals a single one yielded a positive culture — after enrichment.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1984.tb00721.x