A-16686, A NEW ANTIBIOTIC FROM ACTINOPLANES: II. BIOLOGICAL PROPERTIES

A-16686, a new glycoproteide antibiotic obtained from fermentation of an Actinoplanes strain, is active against Gram-positive aerobic and anaerobic bacteria; MIC values ranged from 0.016 to 2.0 μg/ml. A-16686 is bactericidal for growing cells of Staphylococcus aureus, S. epidermidis, Streptococcus f...

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(4), pp.318-324
Main Authors: PALLANZA, R., BERTI, M., SCOTTI, R., RANDISI, E., ARIOLI, V.
Format: Article
Language:English
Subjects:
Actinoplanes
Ampicillin - toxicity
Anti-Bacterial Agents - toxicity
Antibacterial agents
antibiotic A-16686
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Depsipeptides
Glycopeptides - toxicity
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Peptides, Cyclic
Pharmacology. Drug treatments
Species Specificity
Staphylococcus
Streptococcus
Vancomycin - toxicity
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Description
Summary:A-16686, a new glycoproteide antibiotic obtained from fermentation of an Actinoplanes strain, is active against Gram-positive aerobic and anaerobic bacteria; MIC values ranged from 0.016 to 2.0 μg/ml. A-16686 is bactericidal for growing cells of Staphylococcus aureus, S. epidermidis, Streptococcus faecalis, S. faecium, S. mutans, S. mitis and S. sanguis. There is no cross-resistance with clinically used antibiotics. A-16686, administered subcutaneously, is very effective in experimental S. pyogenes and S. pneumoniae septicemias in the mouse.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.318