Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system

Human lymphoblastoid interferon strongly increased the anti-tumor activity of suboptimal doses of two commonly used anti-cancer drugs, cyclophosphamide and Adriamycin, on a human breast tumor xenograft growing in nude mice. A combination of human lymphoblastoid interferon with either of these agents...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-03, Vol.44 (3), p.904-908
Main Authors: BALKWILL, F. R, MOODIE, E. M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Breast Neoplasms - physiopathology
Cell Line
Cell Survival - drug effects
Chemotherapy
Cyclophosphamide - toxicity
Doxorubicin - toxicity
Drug Evaluation, Preclinical
Female
Humans
Interferon Type I - pharmacology
Kinetics
Medical sciences
Mice
Mice, Nude
Neoplasm Transplantation
Pharmacology. Drug treatments
Transplantation, Heterologous
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Summary:Human lymphoblastoid interferon strongly increased the anti-tumor activity of suboptimal doses of two commonly used anti-cancer drugs, cyclophosphamide and Adriamycin, on a human breast tumor xenograft growing in nude mice. A combination of human lymphoblastoid interferon with either of these agents caused regression and in some cases total disappearance of tumors at doses of drug and interferon that, used singly, were capable only of inhibiting tumor growth. The combined therapy also resulted in a greatly increased survival. Studies with interferon and cyclophosphamide indicated that the antitumor activity was greatest when the two agents were administered simultaneously rather than sequentially.
ISSN:0008-5472
1538-7445