Phorbol Ester Receptors: Autoradiographic Identification in the Developing Rat

Autoradiography with $^{3}$H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18- day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-12, Vol.222 (4627), p.1036-1038
Main Authors: Murphy, K. M. M., Gould, R. J., Oster-Granite, M. L., Gearhart, J. D., Snyder, Solomon H.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Biochemistry
Biological and medical sciences
Brain
Brain - embryology
Brain Chemistry
Caenorhabditis elegans Proteins
Cancer
Cancer research
Carrier Proteins
Cell Communication
Cell Division
Cell receptors
Cell research
central nervous system
Central Nervous System - analysis
Central Nervous System - embryology
Cytological research
Enzymes
Eye - embryology
Fetus
Fetus - analysis
General pharmacology
Intestines
Intestines - embryology
Lens, Crystalline - embryology
Liver
Medical sciences
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Phorbol 12,13-Dibutyrate
Phorbol esters
Phorbol Esters - metabolism
Phorbols - metabolism
Photographic slides
Protein Kinase C
Rats
Rats, Inbred Strains
Receptors
Receptors, Cell Surface - analysis
Receptors, Drug
Silver
Spinal cord
Tumors
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Description
Summary:Autoradiography with $^{3}$H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18- day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6316499