Endogenous Pyrogen Activity in Human Plasma after Exercise

Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukoc...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-05, Vol.220 (4597), p.617-619
Main Authors: Cannon, Joseph G., Kluger, Matthew J.
Format: Article
Language:English
Subjects:
Adult
Animals
Bioassay
Blood plasma
Body Temperature - drug effects
Exercise
Female
Fever
Humans
Infections
Interleukin-1
Iron - blood
Leukocytes - physiology
Male
Molecular Weight
Monocytes
Physical Exertion
Plasma temperature
Proteins - physiology
Pyrogen
Pyrogens - blood
Pyrogens - metabolism
Rats
Rats, Inbred Strains
Zinc
Zinc - blood
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Summary:Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6836306