Effects of inhaled HF on lipid metabolism in guinea pigs

Guinea pigs were exposed to hydrogen fluoride (10 mg/m 3) for 84 hr. Plasma triglyceride and cholesterol levels were significantly increased in the treated animals with respect to the controls. An increase in triglyceride levels was also observed in the liver. The metabolism of plasma and hepatic li...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental and applied toxicology 1984-01, Vol.4 (4), p.618-623
Main Authors: Dousset, J.C., Rioufol, C., Feliste, R., Lévy, P., Bourbon, P.
Format: Article
Language:English
Subjects:
Acetates - metabolism
Animals
Apolipoproteins - metabolism
Cholesterol - metabolism
Electrophoresis, Polyacrylamide Gel - methods
Guinea Pigs
Hydrofluoric Acid - toxicity
Isoelectric Focusing
Lipid Metabolism
Lipoprotein Lipase - metabolism
Male
Triglycerides - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Guinea pigs were exposed to hydrogen fluoride (10 mg/m 3) for 84 hr. Plasma triglyceride and cholesterol levels were significantly increased in the treated animals with respect to the controls. An increase in triglyceride levels was also observed in the liver. The metabolism of plasma and hepatic lipids was studied using incorporation of [1- 14C]acetate. Compared to the control group, triglyceride synthesis was accelerated in the liver of the fluoride group. Extrahepatic lipoprotein lipase activity however was decreased in the fluoride group; this could be related to the decrease in apoprotein C.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(84)90052-6