Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus relation to suppressive serum factors

In the present study we examined one aspect of the derangement in natural cytotoxicity (natural killer, NK) activity observed in some patients with systemic lupus erythematosus (SLE), i.e., the lack of enhancement of NK activity usually seen with interferon (IFN). NK activity of SLE patients as a gr...

Full description

Saved in:
Bibliographic Details
Published in:Arthritis and rheumatism 1983-12, Vol.26 (12), p.1452-1459
Main Authors: Sibbitt, W. L., Froelich, C. J., Bankhurst, A. D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
Humans
Immune Sera - immunology
Interferon Type I - immunology
Killer Cells, Natural - immunology
Lupus Erythematosus, Systemic - immunology
Lymphocyte Activation
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study we examined one aspect of the derangement in natural cytotoxicity (natural killer, NK) activity observed in some patients with systemic lupus erythematosus (SLE), i.e., the lack of enhancement of NK activity usually seen with interferon (IFN). NK activity of SLE patients as a group was 23.0 ± 3.9 lytic units (LU)/107 cells (mean ± SE). This contrasted with the NK activity found in normal controls (45.0 ± 3.8 LU/107 cells) (P < 0.05). The enhancement seen with IFN was an increase of 15.4 ± 4.0 LU/107 cells in SLE patients compared with 104.6 ± 192 LU/107 cells in control subjects (P < 0.05). SLE sera and aggregated IgG (Agg‐IgG) also inhibited the increase in NK activity of normal peripheral blood mononuclear cells after IFN priming. The results reported here support the hypothesis that the impaired baseline NK activity and poor response to IFN noted in SLE are secondary, in part, to the presence of inhibitory serum factors and preactivation by IFN.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780261206