TEICHOMYCINS, NEW ANTIBIOTICS FROM ACTINOPLANES TEICHOMYCETICUS NOV. SP: IV. SEPARATION AND CHARACTERIZATION OF THE COMPONENTS OF TEICHOMYCIN (TEICOPLANIN)

Teichomycin (teicoplanin) was found to be a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. The separation of the single components was achieved by reverse phase partition chromatography and their phys...

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(6), pp.615-620
Main Authors: BORGHI, ANGELO, CORONELLI, CAROLINA, FANIUOLO, LUCA, ALLIEVI, GIANCARLO, PALLANZA, ROSETTA, GALLO, GIAN GUALBERTO
Format: Article
Language:English
Subjects:
Actinomycetales - growth & development
Actinoplanes teichomyceticus
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - toxicity
Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid
Lethal Dose 50
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Spectrophotometry
Teicoplanin
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Summary:Teichomycin (teicoplanin) was found to be a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. The separation of the single components was achieved by reverse phase partition chromatography and their physico-chemical and biological properties were compared. The results show that 1) the five major components have the same molecular size of about 1, 900; 2) they contain the same ionizable functions, i.e., a carboxyl group and an amino group which form a zwitterion, and four phenolic groups; 3) they differ in a side aliphatic chain. The component T-A3 is not described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.615