The embryo-fetal toxicity and teratogenic potential of ammounium perfluorooctanoate (APFO) in the rat

Ammonium perfluorooctanoate (APFO, > 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m super(3), or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1984-01, Vol.4 (3), p.429-440
Main Authors: Staples, R E, Burgess, BA, Kerns, W D
Format: Article
Language:English
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Summary:Ammonium perfluorooctanoate (APFO, > 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m super(3), or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among those of the 10-mg/m super(3) group. The fetuses were examined for external, visceral, and skeletal alterations and for APFO-related macroscopic and microscopic alterations of the eyes. In the postpartum period, pups from additional control and experimental dams were examined externally and ophthalmoscopically, and the usual fertility and viability indices were calculated. A teratogenic response was not demonstrated.
ISSN:0272-0590