Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes

Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6- dimethoxysterigmatocystin , versicolorins A and B, averufin , xanthomegnin , luteosporin , a...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-07, Vol.44 (7), p.2918-2923
Main Authors: MORI, H, KAWAI, K, OHBAYASHI, F, KUNIYASU, T, YAMAZAKI, M, HAMASAKI, T, WILLIAMS, G. M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells, Cultured
Chemical mutagenesis
DNA Repair - drug effects
DNA Replication - drug effects
Liver - drug effects
Liver - metabolism
Medical sciences
Mice
Mutagens
Mutation
Mycotoxins - toxicity
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Toxicology
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Summary:Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6- dimethoxysterigmatocystin , versicolorins A and B, averufin , xanthomegnin , luteosporin , and chrysazin , as well as by the carcinogenic myocotoxins , aflatoxin B1, sterigmatocystin, luteoskyrin , ochratoxin A, azaserine, mitomycin C, and actinomycin D. The positive results with compounds of unknown carcinogenicity suggest that they are possibly genotoxic carcinogens. The carcinogenic mycotoxins, penicillic acid, patulin, griseofulvin, and rugulosin , which did not elicit repair synthesis may be nongenotoxic carcinogens.
ISSN:0008-5472
1538-7445