Evolution of haptoglobin: Comparison of complementary DNA encoding Hp alpha super(1S) and Hp alpha super(2ES)

Haptoglobin is a transport glycoprotein which removes free hemoglobin from the circulation of vertebrates. In human populations haptoglobin is polymorphic due to three alleles, Hp alpha super(1F), Hp alpha super(1S) and Hp alpha super(2). In the study described here the authors compare the cDNA enco...

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Bibliographic Details
Published in:Nucleic acids research 1984-01, Vol.12 (11), p.4531-4538
Main Authors: Brune, J L, Yang, F, Barnett, DR, Bowman, B H
Format: Article
Language:English
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Summary:Haptoglobin is a transport glycoprotein which removes free hemoglobin from the circulation of vertebrates. In human populations haptoglobin is polymorphic due to three alleles, Hp alpha super(1F), Hp alpha super(1S) and Hp alpha super(2). In the study described here the authors compare the cDNA encoding Ha) super(1S) to that encoding Hp alpha super(2FS). Both have a leader sequence followed by the genotypic alpha chain sequence, a beta sequence and an untranslated sequence in the 3' end. The cDNA encoding Hp alpha super(2FS) is composed of alpha super(1F) and alpha super(1S) domains differing by four nucleotide replacements. Hp alpha super(1S) cDNA contains the same replacement site mutations found in the alpha super(1S) domain of Hsuper(2)FSi)ndicating that this coding region has sustanined few, if any, mutations since its incroporation into the Hp alpha super(2FS) gene.
ISSN:0305-1048